Endocrine Abstracts

Introduction: There is a lack of epidemiological data on the distribution of haptoglobin and C677T of MTHFR polymorphisms in Caucasians type 2 diabetic patients. The contribution of these two genetic factors to hyperhomocysteinemia and hypercysteinemia can be useful to prevent cardiovascular events and to reduce public health costs. The aim of this study is to evaluate the contribution of haptoglobin and C677T polymorphisms for hyperhomocysteinemia and hypercysteinemia in Port...

Introduction: Treatment satisfaction is simultaneously a cause and consequence of the success of bariatric surgery – not only it is a reflection of the efficacy of treatment, it also enhances weight loss. A questionnaire that evaluates this variable has recently been created and validated by the authors (Post-Bariatric Surgery Satisfaction Questionnaire).Objectives: To identify patients’ expectations regarding bariatric surgery; to identify the...

Introduction: Post-bariatric surgery satisfaction relies on psychosocial and clinical factors. A questionnaire that evaluates this variable has recently been created and validated by the authors (Post-Bariatric Surgery Satisfaction Questionnaire).Objective: To assess the relationship between treatment satisfaction and several demographic and clinical variables.Methods: Patients submitted to bariatric surgery who presented to our Ob...

Introduction: Giant prolactinomas are rare tumours, representing 2–3% of all prolactin (PRL)-secreting tumours. Their definition is restricted to pituitary adenomas with a diameter ≥4 or ≥2 cm of suprasellar extension, very high PRL concentrations (≥1000 ng/ml) and no concomitant GH or ACTH secretion. They are more common in young to middle-aged men. Endocrine symptoms are often present for a long period of time, but most times the diagnosis is made when...

Introduction: Diffuse lipomatosis of the thyroid is a very rare disease, characterized by extensive infiltration of thyroid parenchyma by mature adipose tissue. It is not accompanied by accumulation of amyloid fibrils.Clinical report: Male, 47 years old, followed in Endocrinology by hypothyroidism, since 13 years old, medicated with levothyroxine, with unremarkable growth and pshicomotor development. In 2002, thyroid echography showed a solid and heterog...

Introduction: Acromegaly is a rare disease caused by an increased secretion of GH, usually derived from a benign pituitary tumor. Women with acromegaly are usually infertile, because of tumoral hypersecretion, compression or surgical sequelae. We can prevent infertility with an adequate treatment. There are some reports describing pregnacies among acromegalic women. It is believed that there is an increased risk of develloping diabetes mellitus and hypertension, especially whe...

Besides its critical functions as a reproductive hormone, 17β-estradiol (E2), plays an important role in the control of energy homeostasis. In experimental animals, reduction of circulating estrogen levels by bilateral ovariectomy leads to the development of obesity, which can be reversed or prevented by E2 treatment. E2 effects on energy balance resemble many similarities to the actions of leptin, key molecule involved in the control of e...

Introduction: Pheochromocytomas/paragangliomas are rare neuroendocrine tumors. Although mostly sporadic, about 1/3 of the cases correspond to inherited autosomal dominant syndromes, often associated with germline mutations of the SDHD, SDHC and SDHB genes. The association with the SDHAF2(SDH5) gene has been recently discovered, with only few cases published worldwide, and it presents as a paraganglioma of the head and neck, without previous known description of other locations...

Background: Adrenal insufficiency (AI) is a rare condition affecting children, potentially life-threatening. Autoimmune adrenalitis accounts for 15% of all cases of primary adrenal insufficiency in pediatric age. Most symptoms are usually unspecific, making the diagnosis quite challenging.Objective: The aim of the study was to describe clinical presentation, biochemical abnormalities, treatment and the clinical course of patients with autoimmune AI.<...

Introduction: Metabolic dysfunction-associated steatotic liver disease (MASLD, formerly called non-alcoholic fatty liver disease, NAFLD) is a leading cause of chronic liver disease, affecting 25% adult population worlwide. Its most advanced form is the metabolic dysfunction-associated steatohepatitis, or MASH which may progress to cirrhosis. It has no approved pharmacotherapy yet, and weight reduction is an important therapeutic option. Few studies have evaluated the effect of...